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- Erythrocytosis has been reported as a possible impact of testosterone, which could be useful in patients with anemia.
- The greatest risk of erythrocytosis happens with injectable forms of testosterone compared with transdermal preparations, especially in supraphysiologic doses.
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In addition, the info out there in the literature doesn’t account for the steroid sort or dose, as neither may be identified. Patients additionally may be taking concomitant stimulants, such as ephedra, which might confound data and the potential for adverse occasions. It is likely that the frequency of cardiac events is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 natural and synthetic derivatives of testosterone, might cause a wide spectrum of scientific sequalae.
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac risk components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person additionally had polycythemia, likely secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the right coronary artery. Physicians and sufferers ought to be conscious of the scientific consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity.
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